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Development of the CCQ
The Development of the CCQ is published in:
Health Qual Life Outcomes. 2003 Apr 28;1(1):13.
The full-text article can be found at: http://www.hqlo.com/content/1/1/13
BACKGROUND:
The new Global Obstructive Lung Disease (GOLD) guidelines advice to
focus treatment in Chronic Obstructive Pulmonary Disease (COPD) on
improvement of functional state, prevention of disease progression and
minimization of symptoms. So far no validated questionnaires are
available to measure symptom and functional state in daily clinical
practice. The aim of this study was to develop and validate the
Clinical COPD Questionnaire (CCQ).
METHODS:
Qualitative research with patients and clinicians was performed to
generate possible items to evaluate clinical COPD control. Thereafter,
an item reduction questionnaire was sent to 77 international experts.
Sixty-seven experts responded and the 10 most important items, divided
into 3 domains (symptoms, functional and mental state) were included in
the CCQ (scale: 0 = best, 6 = worst).
RESULTS:
Cross-sectional data were collected from 119 subjects (57 COPD, GOLD
stage I-III; 18 GOLD stage 0 and 44 (ex)smokers). Cronbach's alpha was
high (0.91). The CCQ scores in patients (GOLD 0-III) were significantly
higher than in healthy (ex)smokers. Furthermore, significant
correlations were found between the CCQ total score and domains of the
SF-36 (rho = 0.48 to rho = 0.69) and the SGRQ (rho = 0.67 to rho =
0.72). In patients with COPD, the correlation between the CCQ and
FEV1%pred was rho =-0.49. Test-retest reliability was determined in 20
subjects in a 2-week interval (Intra Class Coefficient = 0.94).
Thirty-six smokers with and without COPD showed significant improvement
in the CCQ after 2 months smoking cessation, indicating the
responsiveness of the CCQ.
CONCLUSION: The
CCQ is a self-administered questionnaire specially developed to measure
clinical control in patients with COPD. Data support the validity,
reliability and responsiveness of this short and easy to administer
questionnaire.
The Minimal Clinically Important difference of the CCQ is 0.4. This was published in Respiratory Research.
Health status measurement in COPD: the minimal clinically important difference of the clinical COPD questionnaire
Respiratory Research 2006, 7:62
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